The richest 1% of the UK population owns more than 20 times the wealth of the poorest fifth, according to Oxfam.
That made Britain one of the most unequal countries in the developed world and contributed to the vote for Brexit, the charity said.
Its analysis found that about 634,000 Britons were worth 20 times as much as the poorest 13 million people.
Oxfam has urged Prime Minister Theresa May to help close the gap between the "haves" and the "have-nots".
The charity's report analysed data from Credit Suisse and found that the richest 10% of the UK population own over half of the country's total wealth, with the top 1% owning nearly a quarter (23%). The poorest 20% share just 0.8% of the UK's wealth between them.
The report said many people in the UK felt locked out of politics and economic opportunity.
"Whatever your views on Brexit, the referendum brought divisions within our country to a head, with many people expressing distrust and disconnection with political processes and voting for change in the hope that it would improve their economic position," Oxfam said.
The charity welcomed Mrs May's recognition of the need to reform corporate culture and proposed a series of measures for the government to adopt.
Rachael Orr, head of Oxfam's UK Programme, said: "Inequality is a massive barrier to tackling poverty and has created an economy that clearly isn't working for everyone. While executive pay soars, one in five people live below the poverty line and struggle to pay their bills and put food on the table."
Ending unscrupulous practices must be a central element of the government's plans to reform the economy, she said.
"That means closing wage gaps, incentivising investment in companies' staff and making sure they pay their fair share of taxes," Ms Orr said.
A Downing Street spokesperson said the government had made changes such as bringing in the National Living Wage and reforming the welfare system, but admitted that more needed to be done to help both the poorest in the UK as well as families struggling to make ends meet.